적출관류 간에서 대황, 마황 및 황금이 7-에톡시쿠마린의 대사에 미치는 영향

적출관류 간에서 대황, 마황 및 황금이 7-에톡시쿠마린의 대사에 미치는 영향

In order to study the effects of Rhei rhizoma, Ephedrae herba and Scutellariae radix on hepatic metabolism, we examined the pretreatment effect of those on the metabolism of 7-e thoxycoumarin (EC). Water extracts (1g/kg) of Rhei rhizoma, Ephedrae herba and Scutellariae radix were administered orally...

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Veröffentlicht in:Yaghag-hoi-ji 1998-08, Vol.42 (4), p.422-430
Hauptverfasser: 최기환(Ki Hwan Choi), 김순선(Soon Sun Kim), 박윤주(Youn Joo Park), 정혜주(Hye Joo Chung), 안미령(Mee Ryung Ahn), 서수경(Soo Kyung Suh), 신윤용(Yhun Yhong Sheen), 김동섭(Dong Sup Kim), 장영섭(Young Sup Chang)
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Sprache:kor
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Zusammenfassung:In order to study the effects of Rhei rhizoma, Ephedrae herba and Scutellariae radix on hepatic metabolism, we examined the pretreatment effect of those on the metabolism of 7-e thoxycoumarin (EC). Water extracts (1g/kg) of Rhei rhizoma, Ephedrae herba and Scutellariae radix were administered orally to rats for 7 days, respectively. Livers were then isolated and perfused with 100mcM EC for 2 hours. The metabolites of EC, 7-hydroxycoumarin, sulfate conjugate and glucuronide conjugate were measured in the perfusates. The amount of glucuronide conjugates was decreased in Rhei rhizoma pretreated rats (p
ISSN:0377-9556
2383-9457