Chaetoglobosin A , an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate

Chaetoglobosin A , an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate

In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM...

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Veröffentlicht in:Journal of microbiology and biotechnology 1998-12, Vol.8 (6), p.705-709
Hauptverfasser: Ko, Hack-Ryong, Kim , Bo-Yeon, Ahn , Soon-Cheol, Oh, Won-Keun, Kim, Jin-Hee, Lee, Hyun-Sun, Kim, Hwan-Mook, Han, Sang-Bae, Mheen, Tae-Ick, Ahn, Jong-Seog
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Sprache:kor
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Zusammenfassung:In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.
ISSN:1017-7825
1738-8872