HRccine(HFRS-virus vaccine)의 급성독성

HRccine(HFRS-virus vaccine)의 급성독성

HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body wei...

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Veröffentlicht in:한국독성학회지 1995, Vol.11 (1), p.133-136
Hauptverfasser: 임동문, 백영옥, 김달현, 박관하, 조정식, 이영순
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Sprache:kor
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Zusammenfassung:HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body weight changes, clinical signs and autopsy findings between all treated groups and control group in both animals. Therefore, it was concluded that HRccine is a very safe substance.
ISSN:0258-2368