Isolation of Cytotoxic Compounds from the Leaves of Xanthium strumarium L

Isolation of Cytotoxic Compounds from the Leaves of Xanthium strumarium L

MeOH extract of the leaves of Xanthium strumarium L. were found to have cytotoxic activities against five human tumor cell lines. Cytotoxicity-guided chromatographic fractionation led to the isolation of the ${\alpha}-methylene$ containing sesquiterpenes, xanthatin, 8-epi-xanthatin and 8-epi-tomento...

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Veröffentlicht in:Natural product sciences 1995, Vol.1 (1), p.1-4
Hauptverfasser: Ahn, Jong-Woong, No, Zae-Sung, Ryu, Shi-Yong, Zee, Ok-Pyo, Kim, Seong-Kie
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Sprache:kor
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Zusammenfassung:MeOH extract of the leaves of Xanthium strumarium L. were found to have cytotoxic activities against five human tumor cell lines. Cytotoxicity-guided chromatographic fractionation led to the isolation of the ${\alpha}-methylene$ containing sesquiterpenes, xanthatin, 8-epi-xanthatin and 8-epi-tomentosin. 8-epi-Xanthatin was found to be far more cytotoxic than 8-epi-tomentosin, which lacks the conjugated enone moiety present in 8-epi-xanthatin.
ISSN:1226-3907