A Regioselectio Synthesis of ${\beta}-Lactones$; Bromolactonization of 2-Substituted-1-Cyclohexenyl-1-acetic acid

A Regioselectio Synthesis of ${\beta}-Lactones$; Bromolactonization of 2-Substituted-1-Cyclohexenyl-1-acetic acid

Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acids with 1, 3-dibromo-5, 5-dime-thylhydantoin 9DBH) and potsssium tertiary butoxide (t-BuOK0 in anhydrous DMF was found to proceed in a highly regioselective manner. The reaction predominantly resulted in the formation of ${\betha}-lacton...

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Veröffentlicht in:Archives of pharmacal research 1994, Vol.17 (5), p.327-330
Hauptverfasser: Jew, Snag-Sup, Lee, Hee-Soon, Koo, Bon-Am
Format: Artikel
Sprache:kor
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Zusammenfassung:Bromolactonization of 2-substituted-1-cyclohexenyl-1-acetic acids with 1, 3-dibromo-5, 5-dime-thylhydantoin 9DBH) and potsssium tertiary butoxide (t-BuOK0 in anhydrous DMF was found to proceed in a highly regioselective manner. The reaction predominantly resulted in the formation of ${\betha}-lactones$ (greater than 96%).
ISSN:0253-6269
1976-3786