항진균제 Naftifine 구조와 관련된 알릴아민류의 합성

항진균제 Naftifine 구조와 관련된 알릴아민류의 합성

Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2'e-2'h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH...

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Veröffentlicht in:Yaghag-hoi-ji 1993-06, Vol.37 (3), p.247-253
Hauptverfasser: 김욱(Wook Kim), 박은주(Eun Ju Park), 서희경(Hee Kyong Seo), 신부안(Boo Ahn Shin), 최보길(Bo Gil Choi), 정병호(Byung Ho Chung)
Format: Artikel
Sprache:kor
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Zusammenfassung:Eight new derivatives of allylamine which are related to naftifine and expected to have antifungal activity were synthesized. Schiff base 2a-2d and 2'e-2'h were obtained by conventional methods using trans-cinnamylamine or trans-cinnamaldehyde. The reduction of azomethine linkage with NaBH$_{4}$ yielded secondary amine 3a-3h, which were then methylated by means of HCHO and excess NaBH$_{4}$ or HCOOH to give 4a-4h.
ISSN:0377-9556
2383-9457