Acyclonucleoside류의 합성(7) - 6-아자유리딘의 2'', 3''-seco유도체의 합성

Acyclonucleoside류의 합성(7) - 6-아자유리딘의 2'', 3''-seco유도체의 합성

Synthesis of 6-aza-2´-azido-2´,3´-secouridine, 6-aza-2´,3´-diazido-2´, 3´-secouridine, and 6-aza-5´-azido-2´,3´-secouridine as potential antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety. And these compounds...

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Veröffentlicht in:Yaghag-hoi-ji 1992-12, Vol.36 (6), p.604-610
Hauptverfasser: 신대홍(Dae Hong Shin), 양재욱(Jae Wook Yang), 김중협(Joong Hyup Kim), 정원근(Won Keun Chung), 천문우(Moon Woo Chun)
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Sprache:kor
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Zusammenfassung:Synthesis of 6-aza-2´-azido-2´,3´-secouridine, 6-aza-2´,3´-diazido-2´, 3´-secouridine, and 6-aza-5´-azido-2´,3´-secouridine as potential antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety. And these compounds were tested against HSV-1 and HSV-2, but the in vitro test results of these compounds were negative.
ISSN:0377-9556
2383-9457