Synthesis and Structure of Purine Derivatives as Antitumor Effects

Synthesis and Structure of Purine Derivatives as Antitumor Effects

The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations....

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Veröffentlicht in:Archives of pharmacal research 1989, Vol.12 (2), p.138-142
Hauptverfasser: Moharram, H.H, El-Bayouki, Khairy A.M, Haggag, B, Basyouni, W.M, Osman, A.M
Format: Artikel
Sprache:kor
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Zusammenfassung:The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.
ISSN:0253-6269
1976-3786