혈당변동성과 당뇨병

Not only mean blood glucose, but also ‘glycemic variability,’ the degree of fluctuation in blood glucose, has been suggested to contribute to diabetic complications. Glycemic variability can be expressed with various indices, such as standard deviation, coefficient of variation (CV), mean amplitude of glycemic excursion, etc.; however, standard indicators have not been established. Recently, CV was designated in cases of application of continuous glucose monitoring system according to international consensus. In this review, clinical implications of glycemic variability are dealt with respect to micro- and macrovascular complications of diabetes, and clinical evidence of new anti-diabetics are summarized about efficacy on the glycemic variability.