Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN...
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| Veröffentlicht in: | The Korean journal of internal medicine 2014-03, Vol.29 (2), p.176 |
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| creator | Ji Hye Lee Mee Hye Oh Jae Seok Park Gyoung Jae Na Hye Wook Gil Jong Oh Yang Eun Young Lee Sae Yong Hong |
| description | Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/ uPAR expression against interstitial fibrosis. |
| format | Article |
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Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/ uPAR expression against interstitial fibrosis.</description><identifier>ISSN: 1226-3303</identifier><identifier>EISSN: 2005-6648</identifier><language>kor</language><publisher>대한내과학회</publisher><subject>Glomerulonephritis ; IGA ; Plasminogen activator inhibitor 1 ; Receptors ; urokinase plasminogen activator ; Urokinase- type plasminogen activator</subject><ispartof>The Korean journal of internal medicine, 2014-03, Vol.29 (2), p.176</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Ji Hye Lee</creatorcontrib><creatorcontrib>Mee Hye Oh</creatorcontrib><creatorcontrib>Jae Seok Park</creatorcontrib><creatorcontrib>Gyoung Jae Na</creatorcontrib><creatorcontrib>Hye Wook Gil</creatorcontrib><creatorcontrib>Jong Oh Yang</creatorcontrib><creatorcontrib>Eun Young Lee</creatorcontrib><creatorcontrib>Sae Yong Hong</creatorcontrib><title>Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis</title><title>The Korean journal of internal medicine</title><addtitle>The Korean Journal of Internal Medicine</addtitle><description>Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/ uPAR expression against interstitial fibrosis.</description><subject>Glomerulonephritis</subject><subject>IGA</subject><subject>Plasminogen activator inhibitor 1</subject><subject>Receptors</subject><subject>urokinase plasminogen activator</subject><subject>Urokinase- type plasminogen activator</subject><issn>1226-3303</issn><issn>2005-6648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9jMtqAkEQRZtgIIPxC9zUBzjQD23cihj8ALOWnplKLOwXXTMS1_nx9EK3gQt1ilN1X0Sjpdy01q63M9EorW1rjDRvYsFMnZRGKavkphG_nyVdKTrGFUxPhII95jGVFbg4QPaOA8X0jRFcP9LNVQUUL9RRpVYB_uSCtTlFqMlpSP19RK43QCFM9dWnbvJ13UHFgGXyKWK-FBqJ38Xrl_OMi8eci-XH4bQ_tldiPudCwZX72WhljV6b_-0f0nxP8Q</recordid><startdate>20140330</startdate><enddate>20140330</enddate><creator>Ji Hye Lee</creator><creator>Mee Hye Oh</creator><creator>Jae Seok Park</creator><creator>Gyoung Jae Na</creator><creator>Hye Wook Gil</creator><creator>Jong Oh Yang</creator><creator>Eun Young Lee</creator><creator>Sae Yong Hong</creator><general>대한내과학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>20140330</creationdate><title>Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis</title><author>Ji Hye Lee ; Mee Hye Oh ; Jae Seok Park ; Gyoung Jae Na ; Hye Wook Gil ; Jong Oh Yang ; Eun Young Lee ; Sae Yong Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kiss_primary_32163243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2014</creationdate><topic>Glomerulonephritis</topic><topic>IGA</topic><topic>Plasminogen activator inhibitor 1</topic><topic>Receptors</topic><topic>urokinase plasminogen activator</topic><topic>Urokinase- type plasminogen activator</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji Hye Lee</creatorcontrib><creatorcontrib>Mee Hye Oh</creatorcontrib><creatorcontrib>Jae Seok Park</creatorcontrib><creatorcontrib>Gyoung Jae Na</creatorcontrib><creatorcontrib>Hye Wook Gil</creatorcontrib><creatorcontrib>Jong Oh Yang</creatorcontrib><creatorcontrib>Eun Young Lee</creatorcontrib><creatorcontrib>Sae Yong Hong</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>The Korean journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji Hye Lee</au><au>Mee Hye Oh</au><au>Jae Seok Park</au><au>Gyoung Jae Na</au><au>Hye Wook Gil</au><au>Jong Oh Yang</au><au>Eun Young Lee</au><au>Sae Yong Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis</atitle><jtitle>The Korean journal of internal medicine</jtitle><addtitle>The Korean Journal of Internal Medicine</addtitle><date>2014-03-30</date><risdate>2014</risdate><volume>29</volume><issue>2</issue><spage>176</spage><pages>176-</pages><issn>1226-3303</issn><eissn>2005-6648</eissn><abstract>Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/ uPAR expression against interstitial fibrosis.</abstract><pub>대한내과학회</pub><tpages>7</tpages></addata></record> |
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| ispartof | The Korean journal of internal medicine, 2014-03, Vol.29 (2), p.176 |
| issn | 1226-3303 2005-6648 |
| language | kor |
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| source | KoreaMed Synapse; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Glomerulonephritis IGA Plasminogen activator inhibitor 1 Receptors urokinase plasminogen activator Urokinase- type plasminogen activator |
| title | Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis |
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