Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis

Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN...

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Veröffentlicht in:The Korean journal of internal medicine 2014-03, Vol.29 (2), p.176
Hauptverfasser: Ji Hye Lee, Mee Hye Oh, Jae Seok Park, Gyoung Jae Na, Hye Wook Gil, Jong Oh Yang, Eun Young Lee, Sae Yong Hong
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Sprache:kor
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Zusammenfassung:Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/ uPAR expression against interstitial fibrosis.
ISSN:1226-3303
2005-6648