Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis

Background/Aims: Spontaneous bacterial peritonitis (SBP) has been known to greatly influence the survival rate of patients with liver cirrhosis. However, the factors that affect the survival rate in patients with SBP need to be clarified. Methods: This study enrolled 95 liver cirrhosis patients diagnosed with SBP. The laboratory findings of their serum and ascetic fluid were examined and the characteristics of the isolated microorganisms in their peritoneal fluid were analyzed. Results: The proportion of patients with culture-positive SBP was 41.1%, and 47 microorganisms were isolated from the ascetic fluid. The proportions of cultured bacteria that were Gram negative and Gram positive were 57.4% and 40.4%, respectively. The proportions of Escherichia coli, Klebsiella species, and Streptococcus species were 25.5%, 19.1%, and 19.1%, respectively. Enterococcus species represented 12.8% of the microorganisms cultured. The overall survival rates at 6, 12, and 24 months were 44.5%, 37.4%, and 32.2%, respectively. There was no relationship between the bacterial factors and the survival rate in SBP. Multivariate analysis revealed that the presence of hepatocellular carcinoma (HCC; P=0.001), higher serum bilirubin levels (≥3 mg/dL, P=0.002), a prolonged serum prothrombin time (I.e., international normalized ratio>2.3, p1.3 mg/dL, P