Case Reports : Two Cases of Generalized Granuloma Annulare in Infants

Generalized granuloma annulare (GGA) is characterized by disseminated necrotic dermal papules but the pathogenesis has not been fully elucidated. A 5-month and a 3-month male infant had diffusely scattered, erythematous papules on their trunks, and upper and lower extremities. Histopathological examination revealed an infiltration of histiocytes around and between altered collagen fibers in upper and mid dermis. The collagen fibers were separated by mucin, which was positively stained with alcian blue at pH 2.5. After they were treated with topical and/or systemic corticosteroid, the lesions disappeared. To the best of our knowledge, these two cases are non-perforating GGA in the youngest patients yet reported in English literature. (Ann Dermatol (Seoul) 19(3) 122~125, 2007)