아토피피부염 영아에서 유아식 유형에 따른 임상증상, 영양상태 및 면역지표의 변화

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in the early age of life, and AD and food allergy often simultaneously occur in the same patient. Objective: The purpose of this study was to investigate the effects of soy formula as compared with extensively hydrolyzed cow`s milk formula in infants with AD. Method: Subjects were supplemented with extensively hydrolyzed cow`s milk formula (HCF group, n=16) or soy formula (SF group, n=13) through dietary counseling for 12 weeks. The degree of severity of AD symptoms were measured using the scoring atopic dermatitis (SCORAD) index. Cow`s milk allergy was confirmed on the basis of a history of allergic reaction to cow`s milk, a positive result from skin prick test (SPT), and the presence of immunoglobulin E (IgE) antibodies to cow`s milk. Dietary assessment were performed. Anthropometric indices were compared with standard values of growth and development for Korean children. Blood samples were collected to analyze RBC fatty acids composition and immune markers. Result: The AD infants` weights and heights were within normal range. The SCORAD index after 12 weeks improved significantly (P＜0.01). The composition of DHA of erythrocyte decreased in the HCF and SF groups. There were no significant differences in changes of total serum IgE concentration between both groups. Serum levels of IL-5, IL-13 and TNF-α decreased significantly after the supplementation of extensively hydrolyzed cow`s milk. Conclusion: Extensively hydrolyzed cow`s milk and soy formulas may support normal growth of infants and improved the symptoms of AD to the same degree. Prospective long-term studies are needed to investigate the significant effects and the mechanism of each formula in AD infants. (Korean J Asthma Allergy Clin Immunol 2007;27:33-42)