안정된 복막투석 환자에서 혈청 알부민 치 변화에 관여하는 인자 분석

Background : Hypoalbuminemia is the most important risk factor for death in dialysis patients. But, it is not well know the factors determining the changes of serum albumin with time. The present study attempts to address the changes of albumin with time and the factors determining the changes of serum albumin in stable patients on peritoneal dialysis. Methods : Fifty-four peritoneal dialysis patients in stable condition were included. Serum albumin, peritoneal equilibration test, weekly urea clearance (Kt/V), weekly creatinine clearance(CCr) and normalized protein catabolic rate(nPCR) were determined two times(mean 5.8±2.3 months and 31.3±6.5 months after initiation of peritoneal dialysis). Results : Initially lower serum albumin group patients(below 3.7 g/dL) showed significantly increased serum albumin level with time(3.2±0.43 g/dL vs 3.57±0.52 g/dL, p=0.006) and initially higher serum albumin group patients(above 3.7 g/dL) showed decreased serum albumin level with time(4.07±0.32 g/dL vs 3.97±0.3 g/dL, p=0.15). Serum albumin changes(Δ) were significantly higher in initially lower serum albumin group than higher serum albumin group(0.37±0.6 g/dL vs -0.11±0.3 g/dL, p