내당능장애군 및 새로 진단된 제 2 형 당뇨병 환자에서 혈장 프로인슐린의 분비양상

Background: Type 2 diabetes mellitus is characterized beta cell dysfunction and insulin resistance but the relative roles of the two factors are different in various ethnic groups. The changes in plasma proinsulin levels is thought to be a marker for the beta-cell dysfunction. To study the role of beta cell dysfunction in the pathogenesis of type 2 diabetes mellitus we compared the concentrations of plasma insulin, C-peptide and proinsulin among the control group, impaired glucose tolerance(IGT) group and newly diagnosed Type 2 Diabetes Mellitus(DM) group during the oral glucose tolerance test. Methods: In 47 newly diagnosed patients with type 2 DM, 9 IGT and 13 controls the 75g oral glucose tolerance test(OGTT) were performed and samples were analyzed for glucose, insulin, C-peptide and proinsulin. Results: 1) In IGT group plasma insulin, C-peptide and proinsulin concentrations were increased markedly during OGTT but were blunted in type 2 diabetes group. 2) The basal plasma proinsulin level was 7.7±4.4pmol/L in control group, 15.2±6.9 pmol/L(p