건강 성인에서 라니티딘(300mg)과 오메프라졸(10mg, 20mg)의 위식도역류 및 위내 pH에 대한 효과

Background/Aims : This study was done to compare the effects of Omeprazole (OMD) 10 or 20 mg with Ranitidine(RAN) 300 mg on intragastric acidity and gastroesophageal reflux in healthy subjects. Methods : Ten healthy male volunteers were studied after administrations of 5 days dosing with either RAN 300 mg, OMD 10 mg or 20 mg, once each morning. On the 5th day, intragastric pH and lower esophageal pH were measured by a dual channel antimony pH catheter for 10 hours. Results : Gastroesophageal reflux was reduced after administrations of RAN 300 mg, OMD 10 mg or 20 mg (p0.05). The gastric holding time of pH >4 was significantly prolonged over fasting and postprandial periods after RAN 300 mg, OMD 10 mg or 20 mg administrations (p