식괴의 종류에 따른 식도운동의 변화에 관한 연구

Background/Aims: It is suggested that diffuse esophagenl spasm (DES), nutcracker esophagus (NUT), and hypertensive lower esophageal sphincter (HLES) could be re-classified together as a spastic esophageal motility disorder of similar clinical background. However, there were no studies to evaluate the pathophysiological characteristics of these motor abnormalities. The aim of the study was to evaluate the changes of esophageal motor function depending on the different types of the bolus (water vs semi-solid bolus). Methods: Twenty-one healthy subjects and 42 subjects with primary esophageal motility disorders (4 DES, 12 NUT, 5 HLES, 12 nonspecific esophageal motility disorders, 9 normal) underwent a perfusion manometry with a low compliance pneumo-hydraulic capillary infusion system. Consecutively, each patient had l0 swallows of water and 10 swallows of Jello, 5 ml each. Results: In the healthy controls, the Jello swallow showed an increased amplitude and duration of distal esophageal contraction, and the velocity of peristalsis was decreased (p