Bezafibrate에 의한 급성 신부전을 동반한 횡문근 융해증 1예

Bezafibrate is a lipid-lowering agent which be- longs to the fibric acid derivatives. Bezafibrate is chemically similar to clofibrate, the latter is known to induce occasinally acute muscular syndrorne with or without renal failure. We report a patient with diabetic nephropathy who had massive rhabdomyoly- sis with acute renal failure due to bezafibrate. A 47-year-old woman was admitted with complaints of general weakness and red urine. She has had rheumatoid arthritis and diabetes mellitus 5 years ago, and mild proteinuria and slight elevation of serum creatinine were noticed since last year. She was given bezafibrate for the control of hyper- cholesterolemia for 1 week. Sudden general myalgia, anorexia, and red urine developed before admissing. Rapid increase in BUN, serum creatinine and muscle enzymes were noted. Increased muscle uptake of technetium-99m MDP were noticed on bone scan. These findings suggest that bezafibrate had provo- ked rhabdomyolysis with acute renal failure.