무마취 가토에서 일측 신장내에 투여한 Angiotensin 1 와 Angiotensin 2 가 신장기능에 미치는 영향

Angiotensins have been proposed to play a key role in the renal regulation of water and electrolyte balance. But a direct effect of angiotensin Iiand angiotensin III on renal function is still controversial. So experiments were carried out in unanesthetized rabbits to compare the changes of renal function after angiotensin II and angiotensin III were infused into the renal artery. Both angiotensin II and angiotensin III caused a dose- dependent decrease on urine volume along with a decrease of GFR, renal blood flow, fractional excretion of sodium, free water clearance and excreted amount of sodium, potassium, and chloride. There was no signifi- cant change of filtration fraction. The changes seemed to be the consequence of increased tubular sodium reabsorption and modulation of glomerular hemodynamics. There was no significant change of blood pressure throughout the infusion. Angiotensin II and angiotensin III appeared to be equipotent in their abilities to change several parameters of renal function. The present study suggests that angiotensin II and angiotensin III appear to share the same receptors in the kidney.