결핵성 뇌막염에 병발된 중추성 요붕증 1 예

Tuberculous menigitis is relatively common disease and delay in treatment is associated with many neurologic sequelae. Of the neurologic disorder, diabets insipidus is extreamly rare. Diabetes insipidus is a syndrome characterized by the excretion of abnormally large volumes of dilute urine. It is divided into central diabets insipidus, nephrogenic diabetes insipidus, primary polydipsia and gestational daibetes insipidus. In this four type of diabetes insipidus, central diabetes insipidus is a polyuric disorder results from a lack of sufficient antidiuretic hormone to effect appropriate concentration of the urine for water conservration. We report a 25-year old male who had prolonged head- ache and subsequently followed by polyuria. He was diagonsed as the tuberculous meningitis by laboratory finding and smear of CSF, and diagnosed central diabetes insipidus by serum osmolality & Na+ & AVP (arginine vasopressin), urine osmolality & specific gravity, administration of vasopressin. He maintained the water balance of body by administration of vasopressin, but without improvement of mental status, sudden cardiac arrest occurs on 20th hospital day