한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계
designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy K...
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| Veröffentlicht in: | The Korean journal of medicine 1998-02, Vol.54 (2), p.217 |
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| container_title | The Korean journal of medicine |
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| creator | 신영신 Young Shin Shin 김영옥 Young Ok Kim 박철휘 Chul Whee Park 윤성노 Sung No Yoon 양철우 Chul Woo Yang 김용수 Yong Soo Kim 장윤식 Yeun Sik Jang 방병기 Byung Kee Bang 한훈 Hoon Han |
| description | designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy Korean people. We evaluated the HLA class I serologic typing by standard microlymphocytotoxic technique and the HLA class II genotypes by the two-step polymerase chain reaction. Results : 1. HLA-A was not associated with IgAN. 2. The phenotype frequency of HLA-B55 was 6.1% in patient group and 1.7% in normal control group. HLA- B55 was associated with IRAN(relative risk 3.47, P |
| format | Article |
| fullrecord | <record><control><sourceid>kiss</sourceid><recordid>TN_cdi_kiss_primary_1887246</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><kiss_id>1887246</kiss_id><sourcerecordid>1887246</sourcerecordid><originalsourceid>FETCH-LOGICAL-k422-6f8ee64cadfcb6e883c900165bc9271681e980ee69a99f2a8762ac36dcdebd213</originalsourceid><addsrcrecordid>eNpjYeA0NDe20LU0NjPhYOAtLs5MMjA2MLQ0MTEy42Twejt1zquta9_M3fFm-oQ3LXPezJ2h4JnuqPCme8GbeUtfb574ZtncV5v3KLxZuOHN8sY3CxrfTl35pmWjwtupa9_MngCUAWl4taXh1eYWHgbWtMSc4lReKM3NEOLmGuLsoevj7-7p7Oijm21iZKRrlmaRmmpmkpyYkpacZJZqYWGcbGlgYGhmmpRsaWRuaGZhmGppYQBUYploaZlmlGhhbmaUmGxslpKckpqUYmRozM0gDTE2O7O4OL6gKDM3sagy3tDCwtzIxMwYAA1-W7Y</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계</title><source>KoreaMed Open Access</source><creator>신영신 ; Young Shin Shin ; 김영옥 ; Young Ok Kim ; 박철휘 ; Chul Whee Park ; 윤성노 ; Sung No Yoon ; 양철우 ; Chul Woo Yang ; 김용수 ; Yong Soo Kim ; 장윤식 ; Yeun Sik Jang ; 방병기 ; Byung Kee Bang ; 한훈 ; Hoon Han</creator><creatorcontrib>신영신 ; Young Shin Shin ; 김영옥 ; Young Ok Kim ; 박철휘 ; Chul Whee Park ; 윤성노 ; Sung No Yoon ; 양철우 ; Chul Woo Yang ; 김용수 ; Yong Soo Kim ; 장윤식 ; Yeun Sik Jang ; 방병기 ; Byung Kee Bang ; 한훈 ; Hoon Han</creatorcontrib><description>designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy Korean people. We evaluated the HLA class I serologic typing by standard microlymphocytotoxic technique and the HLA class II genotypes by the two-step polymerase chain reaction. Results : 1. HLA-A was not associated with IgAN. 2. The phenotype frequency of HLA-B55 was 6.1% in patient group and 1.7% in normal control group. HLA- B55 was associated with IRAN(relative risk 3.47, P<0.05). 3. HLA-DQB1*04 was also associated with IgAN (relative risk 3.57, P<0.05). 4. There was no significant difference in the distribution of HLA in IgAN patients according to histologic grading, blood pressure, renal function and proteinuria. Conclusions : Frequencies of HLA-B55, HLA-DQB1*04 are higher in Korean patients with IgAN compared to general population. But we could not observe the significant relationships between HLA type and poor prognostic factors. Further study using larger population with IgAN may be necessary to identify the association of HLA locus with poor prognostic factors and progress decline in renal function in patients with IgAN.</description><identifier>ISSN: 1738-9364</identifier><language>kor</language><publisher>대한내과학회</publisher><subject>HLA ; IgA nephropathy ; Korean ; poor prognostic factor</subject><ispartof>The Korean journal of medicine, 1998-02, Vol.54 (2), p.217</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>신영신</creatorcontrib><creatorcontrib>Young Shin Shin</creatorcontrib><creatorcontrib>김영옥</creatorcontrib><creatorcontrib>Young Ok Kim</creatorcontrib><creatorcontrib>박철휘</creatorcontrib><creatorcontrib>Chul Whee Park</creatorcontrib><creatorcontrib>윤성노</creatorcontrib><creatorcontrib>Sung No Yoon</creatorcontrib><creatorcontrib>양철우</creatorcontrib><creatorcontrib>Chul Woo Yang</creatorcontrib><creatorcontrib>김용수</creatorcontrib><creatorcontrib>Yong Soo Kim</creatorcontrib><creatorcontrib>장윤식</creatorcontrib><creatorcontrib>Yeun Sik Jang</creatorcontrib><creatorcontrib>방병기</creatorcontrib><creatorcontrib>Byung Kee Bang</creatorcontrib><creatorcontrib>한훈</creatorcontrib><creatorcontrib>Hoon Han</creatorcontrib><title>한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계</title><title>The Korean journal of medicine</title><addtitle>대한내과학회지 (Korean J Med)</addtitle><description>designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy Korean people. We evaluated the HLA class I serologic typing by standard microlymphocytotoxic technique and the HLA class II genotypes by the two-step polymerase chain reaction. Results : 1. HLA-A was not associated with IgAN. 2. The phenotype frequency of HLA-B55 was 6.1% in patient group and 1.7% in normal control group. HLA- B55 was associated with IRAN(relative risk 3.47, P<0.05). 3. HLA-DQB1*04 was also associated with IgAN (relative risk 3.57, P<0.05). 4. There was no significant difference in the distribution of HLA in IgAN patients according to histologic grading, blood pressure, renal function and proteinuria. Conclusions : Frequencies of HLA-B55, HLA-DQB1*04 are higher in Korean patients with IgAN compared to general population. But we could not observe the significant relationships between HLA type and poor prognostic factors. Further study using larger population with IgAN may be necessary to identify the association of HLA locus with poor prognostic factors and progress decline in renal function in patients with IgAN.</description><subject>HLA</subject><subject>IgA nephropathy</subject><subject>Korean</subject><subject>poor prognostic factor</subject><issn>1738-9364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0NDe20LU0NjPhYOAtLs5MMjA2MLQ0MTEy42Twejt1zquta9_M3fFm-oQ3LXPezJ2h4JnuqPCme8GbeUtfb574ZtncV5v3KLxZuOHN8sY3CxrfTl35pmWjwtupa9_MngCUAWl4taXh1eYWHgbWtMSc4lReKM3NEOLmGuLsoevj7-7p7Oijm21iZKRrlmaRmmpmkpyYkpacZJZqYWGcbGlgYGhmmpRsaWRuaGZhmGppYQBUYploaZlmlGhhbmaUmGxslpKckpqUYmRozM0gDTE2O7O4OL6gKDM3sagy3tDCwtzIxMwYAA1-W7Y</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>신영신</creator><creator>Young Shin Shin</creator><creator>김영옥</creator><creator>Young Ok Kim</creator><creator>박철휘</creator><creator>Chul Whee Park</creator><creator>윤성노</creator><creator>Sung No Yoon</creator><creator>양철우</creator><creator>Chul Woo Yang</creator><creator>김용수</creator><creator>Yong Soo Kim</creator><creator>장윤식</creator><creator>Yeun Sik Jang</creator><creator>방병기</creator><creator>Byung Kee Bang</creator><creator>한훈</creator><creator>Hoon Han</creator><general>대한내과학회</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>19980201</creationdate><title>한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계</title><author>신영신 ; Young Shin Shin ; 김영옥 ; Young Ok Kim ; 박철휘 ; Chul Whee Park ; 윤성노 ; Sung No Yoon ; 양철우 ; Chul Woo Yang ; 김용수 ; Yong Soo Kim ; 장윤식 ; Yeun Sik Jang ; 방병기 ; Byung Kee Bang ; 한훈 ; Hoon Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k422-6f8ee64cadfcb6e883c900165bc9271681e980ee69a99f2a8762ac36dcdebd213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1998</creationdate><topic>HLA</topic><topic>IgA nephropathy</topic><topic>Korean</topic><topic>poor prognostic factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>신영신</creatorcontrib><creatorcontrib>Young Shin Shin</creatorcontrib><creatorcontrib>김영옥</creatorcontrib><creatorcontrib>Young Ok Kim</creatorcontrib><creatorcontrib>박철휘</creatorcontrib><creatorcontrib>Chul Whee Park</creatorcontrib><creatorcontrib>윤성노</creatorcontrib><creatorcontrib>Sung No Yoon</creatorcontrib><creatorcontrib>양철우</creatorcontrib><creatorcontrib>Chul Woo Yang</creatorcontrib><creatorcontrib>김용수</creatorcontrib><creatorcontrib>Yong Soo Kim</creatorcontrib><creatorcontrib>장윤식</creatorcontrib><creatorcontrib>Yeun Sik Jang</creatorcontrib><creatorcontrib>방병기</creatorcontrib><creatorcontrib>Byung Kee Bang</creatorcontrib><creatorcontrib>한훈</creatorcontrib><creatorcontrib>Hoon Han</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>The Korean journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>신영신</au><au>Young Shin Shin</au><au>김영옥</au><au>Young Ok Kim</au><au>박철휘</au><au>Chul Whee Park</au><au>윤성노</au><au>Sung No Yoon</au><au>양철우</au><au>Chul Woo Yang</au><au>김용수</au><au>Yong Soo Kim</au><au>장윤식</au><au>Yeun Sik Jang</au><au>방병기</au><au>Byung Kee Bang</au><au>한훈</au><au>Hoon Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계</atitle><jtitle>The Korean journal of medicine</jtitle><addtitle>대한내과학회지 (Korean J Med)</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>54</volume><issue>2</issue><spage>217</spage><pages>217-</pages><issn>1738-9364</issn><abstract>designed to evaluate the pattern of histocompatibility antigens(HLA) and its association with poor prognostic factors in patients with IgAN. Methods : Study population comprised the 69 patients with IgAN which was diagnosed by clinical and pathological findings, and control groups were 202 healthy Korean people. We evaluated the HLA class I serologic typing by standard microlymphocytotoxic technique and the HLA class II genotypes by the two-step polymerase chain reaction. Results : 1. HLA-A was not associated with IgAN. 2. The phenotype frequency of HLA-B55 was 6.1% in patient group and 1.7% in normal control group. HLA- B55 was associated with IRAN(relative risk 3.47, P<0.05). 3. HLA-DQB1*04 was also associated with IgAN (relative risk 3.57, P<0.05). 4. There was no significant difference in the distribution of HLA in IgAN patients according to histologic grading, blood pressure, renal function and proteinuria. Conclusions : Frequencies of HLA-B55, HLA-DQB1*04 are higher in Korean patients with IgAN compared to general population. But we could not observe the significant relationships between HLA type and poor prognostic factors. Further study using larger population with IgAN may be necessary to identify the association of HLA locus with poor prognostic factors and progress decline in renal function in patients with IgAN.</abstract><pub>대한내과학회</pub><tpages>10</tpages></addata></record> |
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| issn | 1738-9364 |
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| source | KoreaMed Open Access |
| subjects | HLA IgA nephropathy Korean poor prognostic factor |
| title | 한국인에서의 IgA 신장병증과 조직적합성 항원과의 관계 |
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