관동맥 질환 환자에서 Lipoprotein ( a ) 농도와 당내인성과 관련성

Objectives: A raised Lp (a) lipoprotein concentration is associated with coronary artery disease and impaired glucose intolerance has also been shown to be predictive of coronary artery clisease in some studies. It has been suggested that there is a significant association between impaired glucose tolerance and increased circulating Lp (a) lipoprotein concentration. The object of this study is to determine whether glucose intolerance and raised Lp (a) concentration are associated in subjects with coronary artery disease. Methods: The study group comprised 60 patients with coronary artery disease (M:20, mean age 56+/-13 year) and 70 control subjects without coronary artery disease (M:15, mean age 58+/-10 year). We compared the clinical variables, lipid profile including Lp (a), fasting glucose, and fasting insulin in subjects with coronary artery disease with impaired glucose tolerance and normal glucose tolerance, and in controls. Results: 1) Nine of 60 patients (15%) with coronary artery disease had glucose intolerance. There were no significant difference in the incidence of cardiovascular risk factors, body mass index, left ventricular mass index, the levels of lipid including Lp (a), and the levels of fasting glucose, insulin, and C-peptide except in the incidence of smoking (48% in patients with coronary artery disease vs 24% in normal control, p