제 3 형 자가면역성 다선 증후군 5 예

Polyglandular autoimmune(PGA) syndrome is complex autoimmune disorder that two or more organs are involved by organ specific autoantibodies. We report here 5cases of polyglandular autoimmune syndrome type 3 which consist of autoimmune thyroid disease(Hashimoto's thyroiditis) and other autoimmune diseases(e.g. systemic lupus erythematosus, rheumatoid arthritis and chronic autoimmune hepatitis). The patients of 5 cases were all females, and the age of 3 patients was 4th decade and that of the remainder was 6th and 7th decade. These diseases represented good response to treament with thyroid hormone and glucocorticoid or nonsteroidal antiinflammatory drug. The follow up of anti thyroid autoantibodies titer was significant in evaluation of treatment of autoimmune thyroid disease. We suggest that, if an endocrine autoimmune disease is detected, we should suspect and diagnose another associated autoimmune diseases as soon as possible.