괴사성 간경변증에서의 골이영양증

Objectives: Patients with chronic liver disease are at increased risk to develop metabolic bone disease. Although the etiology of the osteopathy in patients with primary biliary cirrhosis has not been defined, vitamin D deficiency and calcium malabsorption have been suggested as possible pathogenetic factors. In Korea, Patients with postnecrotic liver cirrhosis due to chronic hepatitis B are numerous, however, data on the prevalence and severity of osteopenia in these patient are rare. This study was performed to elucidate the mechanism of osteopenia and to examine its severity in postnecrotic liver cirrhosis. Methods: Thirty four patients with postnecrotic liver cirrhosis and thirty controls matched in age and sex were included in this study group. To obtain bone mineral density of lumbar spines in postnecrotic liver cirrhosis and control groups, measurements and comparisons of following tests were performed: Dual energy xray absorptimetry, serum calcium, serum osteocalcin, and serum 25 (OH) vitamin D. In addition, initial morning urine sample was collected to measure pyridinoline crosslinks. Results: 1) The average bone density of lumbar spines was 1.03±0.03 gm/cm² in postnecrotic liver cirrhosis group and 1.15±0.02 gm/cm² in normal controls (p