비임신여성 및 임신말기 산모에서 정상 유전자형 Pseudocholinesterase 의 활성도 비교

Background: Many reports on the change of pseudocholinesterase activity in pregnant women showed that it declines during pregnancy and in the immediate postpartum period. In Korea, there are two papers that show dissident results. However, they didnt prove that the subjects in their studies had genotypically normal enzyme. So, we compared the pseudocholinesterase activities between nonpregnant and term-pregnant women who have the genotypically normal enzyme. Methods: We measured the dibucaine, fluoride, chloride number as well as the pseudocholinesterase astivity using butyrylthiocholine as substrate by automatic analyser, urea and scoline numbers using benzoylcholine as substrate by manual technique in nonpregnant(n=15) and term-pregnant(n=15) women aging 20 to 40 years old before induction of anesthesia. Results: The dibucaine, fluoride, chloride, urea and scoline numbers(mean±SD,%) in female subjects were 86±1.2, 50±5.2, 5±2.4, 47±2.8 and 92±2.0, respectively. There were two subjects showing low pseudocholinesterase activity(