마취가 수술환자 간기능에 미치는 영향에 관한 임상적 관찰

it is well known that some inhalation anesthetics and ancillary drugs are metabolized in the liver. Since this fact was reportede (Read, 1672; Dripps. 1977) the influence of different anesthetixs on the liver has been of great interest up to date. The most cause of postoperative hepatic dysfunction seems to be acute viral hepatitis, but there are some other cayses such as anesthetic damage and untoward reactions to the drugs used in the intraoperative or postoperative periods (Babior& Davidson, 1976; Bruce, 19972). Halothane is usually a safe and effectve inhalation anedthetic agent but on occasion it has damaged the liver. Many papers have reported these untoward reactions, and then attention began to be paid to other anesthetic agents. The author seleted random samples of 100 adult female patients who had lower abdominal operations at Won-ju Christian Hospital between May 1982 to August 1982. Their physical status was ASA class I & II, liver function tests were within normal limits and they had no previous histoty og operation or liver diseade. They were divided into five froups according to the anesthetic agent used (halothane, ethrane, ether, Thalamonal neuroleptanedthesia and lidocaine epidural anesthesid\a). the liver function tests were performed before surgety, and on the 1st, 3rd, 5th, and 7th postoperative days. The result were as follows; 1) BUN, total protein, albbumin, globulin and total cholesterol were not significantly changed. 2) The valuse of SGOT & SGPT were slighty increased elavated on the first postop day, and on teh 3rd day after operation and them gradually decreased. On the 7th day after operation they had retutned to the preoperative levels. The changes of teh values were within normal limits. 3) Alkaline phosphatase, tatal bilirutbin and direct bilirubin were not significantly infuenced by the anesthetic agents. It is suggested that the influence of valriable anesthetic agent on the liver is not significant, and that the caanges of the liver function tests were minimal, and the values of the tests have usually returned to normal by the 7th after operation.