슬관절전치환술환자에 대한 척추마취시 Neostigmine 첨가가 술후진통에 미치는 효과
Background : Intrathecal neostigmine causes analgesia in dose-dependent pattern. This study was designed to examine postoperative analgesia with intrathecal neostigmine in a randomized, blinded trial with tetracaine as the active control in patients undergoing total knee replacement(TKR). Methods :...
Gespeichert in:
Veröffentlicht in: | Korean journal of anesthesiology 1998-01, Vol.34 (1), p.121 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | kor |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Background : Intrathecal neostigmine causes analgesia in dose-dependent pattern. This study was designed to examine postoperative analgesia with intrathecal neostigmine in a randomized, blinded trial with tetracaine as the active control in patients undergoing total knee replacement(TKR). Methods : Eighty patients scheduled for TKR were divided into seven groups( Control; no neostigmine, N25, 50, 75, 100, 125 and 150; subarachnoid tetracaine with neostigmine 25, 50, 75, 100, 125 and 150 g, respectively). Postoperatively, patients assessed their pain on a 10-cm visual analog scale(VAS), total analgesic requirement, time to first analgesic rescue medication and side effects were assessed. Results : Increasing doses of intrathecal neostigmine showed a dose-dependent pattern of analgesia defined by the overall VAS scores, time until first administration of rescue analgesic request, and the number of rescue analgesics (p<0.05). Nausea and vomiting was also increased by increasing doses of intrathecal neostigmine(p<0.05). Conclusions : Intrathecal neostigmine with tetracaine produced definitive analgesia in patients undergoing TKR, and neostigmine 75 g resulted in a better analgesic effect with fewer side effects than other doses. (Korean J Anesthesiol 1998; 34: 121∼125) |
---|---|
ISSN: | 2005-6419 2005-7563 |