전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과
Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium. Metho...
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Veröffentlicht in: | Korean journal of anesthesiology 1999-09, Vol.37 (3), p.447 |
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container_title | Korean journal of anesthesiology |
container_volume | 37 |
creator | 오광조 Kwnag Jo Oh 허문수 Moo Soo Heo 고성훈 Seong Hoon Ko 한영진 Yeong Jin Han 최훈 Huhn Choe |
description | Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.
Methods : Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
Results : The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
Conclusions : The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes. (Korean J Anesthesiol 1999; 37: 447∼452) |
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Methods : Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
Results : The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
Conclusions : The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes. (Korean J Anesthesiol 1999; 37: 447∼452)</description><identifier>ISSN: 2005-6419</identifier><identifier>EISSN: 2005-7563</identifier><language>kor</language><publisher>대한마취통증의학회(구 대한마취과학회)</publisher><subject>Analgesia ; magnesium. Pain ; postoperative ; preemptive. Ions</subject><ispartof>Korean journal of anesthesiology, 1999-09, Vol.37 (3), p.447</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>오광조</creatorcontrib><creatorcontrib>Kwnag Jo Oh</creatorcontrib><creatorcontrib>허문수</creatorcontrib><creatorcontrib>Moo Soo Heo</creatorcontrib><creatorcontrib>고성훈</creatorcontrib><creatorcontrib>Seong Hoon Ko</creatorcontrib><creatorcontrib>한영진</creatorcontrib><creatorcontrib>Yeong Jin Han</creatorcontrib><creatorcontrib>최훈</creatorcontrib><creatorcontrib>Huhn Choe</creatorcontrib><title>전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과</title><title>Korean journal of anesthesiology</title><addtitle>Korean Journal of Anesthesiology(구 대한마취과학회지)</addtitle><description>Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.
Methods : Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
Results : The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
Conclusions : The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes. (Korean J Anesthesiol 1999; 37: 447∼452)</description><subject>Analgesia</subject><subject>magnesium. Pain</subject><subject>postoperative</subject><subject>preemptive. Ions</subject><issn>2005-6419</issn><issn>2005-7563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNotjL1Kw1AYQC-iYKl9Apf7AoGb-_fdjFL8g4BL93LTmwuhCtJMbhaCVHHoohZtSwax7mJ18ImSL--gYKdzhsPZIi3OmApAabG9cS3DaJd08jxLmGIgJBjeIjGWBS6n1XqM5RjXc5yUtHkpaHPziW8LfJrS-v66eZjTejWpvr7r4hXvZriYUSzK5vGW4qr4S2nz_F59_OyRHW_P87SzYZv0jg573ZMgPjs-7R7EwVByHoTMJo6xxAx8FPnIDlLNufPSMA469c6FCqRVItIKErDCgGfWAQdunXTMijbZ_98OszzvX46yCzu66ocGDGghfgFmS13H</recordid><startdate>19990930</startdate><enddate>19990930</enddate><creator>오광조</creator><creator>Kwnag Jo Oh</creator><creator>허문수</creator><creator>Moo Soo Heo</creator><creator>고성훈</creator><creator>Seong Hoon Ko</creator><creator>한영진</creator><creator>Yeong Jin Han</creator><creator>최훈</creator><creator>Huhn Choe</creator><general>대한마취통증의학회(구 대한마취과학회)</general><scope>HZB</scope><scope>Q5X</scope></search><sort><creationdate>19990930</creationdate><title>전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과</title><author>오광조 ; Kwnag Jo Oh ; 허문수 ; Moo Soo Heo ; 고성훈 ; Seong Hoon Ko ; 한영진 ; Yeong Jin Han ; 최훈 ; Huhn Choe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-k422-10abd00b8cf99f9ace622df480276efdd1574a539657b7a387f0ad7272ad4d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>1999</creationdate><topic>Analgesia</topic><topic>magnesium. Pain</topic><topic>postoperative</topic><topic>preemptive. Ions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>오광조</creatorcontrib><creatorcontrib>Kwnag Jo Oh</creatorcontrib><creatorcontrib>허문수</creatorcontrib><creatorcontrib>Moo Soo Heo</creatorcontrib><creatorcontrib>고성훈</creatorcontrib><creatorcontrib>Seong Hoon Ko</creatorcontrib><creatorcontrib>한영진</creatorcontrib><creatorcontrib>Yeong Jin Han</creatorcontrib><creatorcontrib>최훈</creatorcontrib><creatorcontrib>Huhn Choe</creatorcontrib><collection>Korean Studies Information Service System (KISS)</collection><collection>Korean Studies Information Service System (KISS) B-Type</collection><jtitle>Korean journal of anesthesiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>오광조</au><au>Kwnag Jo Oh</au><au>허문수</au><au>Moo Soo Heo</au><au>고성훈</au><au>Seong Hoon Ko</au><au>한영진</au><au>Yeong Jin Han</au><au>최훈</au><au>Huhn Choe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과</atitle><jtitle>Korean journal of anesthesiology</jtitle><addtitle>Korean Journal of Anesthesiology(구 대한마취과학회지)</addtitle><date>1999-09-30</date><risdate>1999</risdate><volume>37</volume><issue>3</issue><spage>447</spage><pages>447-</pages><issn>2005-6419</issn><eissn>2005-7563</eissn><abstract>Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.
Methods : Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
Results : The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
Conclusions : The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes. (Korean J Anesthesiol 1999; 37: 447∼452)</abstract><pub>대한마취통증의학회(구 대한마취과학회)</pub><tpages>6</tpages></addata></record> |
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source | DOAJ Directory of Open Access Journals |
subjects | Analgesia magnesium. Pain postoperative preemptive. Ions |
title | 전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과 |
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