전자궁적출술 후 통증에 대한 마그네슘의 선행 진통 효과

Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium. Metho...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Korean journal of anesthesiology 1999-09, Vol.37 (3), p.447
Hauptverfasser: 오광조, Kwnag Jo Oh, 허문수, Moo Soo Heo, 고성훈, Seong Hoon Ko, 한영진, Yeong Jin Han, 최훈, Huhn Choe
Format: Artikel
Sprache:kor
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background : Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium. Methods : Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner. Results : The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups. Conclusions : The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes. (Korean J Anesthesiol 1999; 37: 447∼452)
ISSN:2005-6419
2005-7563