Itopride가 정상 성인에서 상부 위긴장도와 위감각능에 미치는 영향

Background/Aims : Itopride is a newly developed prokinetic agent and has antidopaminergic and anti- acetylcholine esterase activities. Our aim was to evaluate the effect of itopride on proximal gastric tone and visceral perception. Methods: Fifteen healthy subjects participated in two experiments with 7 days interval. Randomized double blinded cross-over design with 3 days pretreatment of placebo or itopride was followed by itopride or placebo treatment. After overnight fasting, itopride was given prior to barostat study. Sensory function was assessed by scoring the perception for nausea, fullness, and abdominal discomfort/pain during random-order distensions of 4, 8, and 12 mmHg above minimal intragastric distending pressure (MDP). Effect of distensions was studied three times. Results : Compliance was not different after pretreatment of itopride or placebo. Itopride has no effect on visceral perception at MDP＋4 mmHg (92.5±45.3 vs. 79.1±30.2), 8 mmHg (117.7±41.1 vs. 118.9±41.5) and at MDP＋12 mmHg (159.8±43.9 vs. 149.9±53.5). MDP and fasting tone were not different between the two experimental groups. After itopride pretreatment, significantly increased intragastric volume were recorded in 60 min postprandial period (p