원발성 간암에 대한 임상적 연구

Hepatocellular carcinama (HCC) has an estimated annual incidance of 1,000,000 worldwise, and two0thirds are patients from Asia, the south Pacific and subsaharan Africa. In Korea, there is evidence that incidance of HCC may be increasing like other country. This study was sone to investigate clinical feature of HCC. 87 patients that was siagnosed Hcc, underwnet laboratory study, ultrasonography, computed tomography and transhepatic arterial embolization(TAE) form July 1989 to June 1992. These patients included 75 men (83.3%) and 12 women (16.7%) whose ages ranged from 32 to 79 years with average of 54.9 years. Underlying cirrhosis of the liver was found in 53.4% of patient, alcohoh abuse was present in 65.2% heavy smoking was present in 69.2%. Hepatitis Bsurface antigen was positive in 81%, IgG Hepatitis Bcore antibody was positive in 92.2%, and alpha-fetoprotein showed a high diagnostic sensitivity (values above 500 ng/mm3 in 73.2% ) . TAE is the relatively effective method of mangement of HCC. The patients who recieved TAE had better prohnosis. HCC that have male predominant occurrance are successive sequale of chronic hetatitis B and C virus infection, and the quantitation of alpha-fetoprotein and advent of ultrasonography have made detection of hepatin mass possible. Therefore, we have suggested study using both alpha-fetoprotein and ultrasonography to screen for asymtomatic HCC in patients with chronic hepatitis.