Cerulein 유도 급성췌장염에서의 활성산소라다칼의 역할

Backgroung/Aims: Oxygen radicals are suggested to be an imponant role in the pathogenesis of acute pancreatitis in experimental animals. Cerulein is closely related to the cholecystokinin and it is a potent stimulant of pancreatic exocrine secretion. The purpose of this study was to evaluate the effect of free oxygen radicals in the cerulein induced acute pancreatitis. Methods: Two groups of male Sprague Dawley rats weighing 380-420gm were studied: control group(n=12), fasted for 12 hours the animals with intraperitoneal injection twice of 0,9% saline with a l-hour interval, and cerulein group(n=20), animals who fasted for 12 hour received two intraperitoneal injections of cerulein at hourly intervals(40 microgram/kg). After 4 hours of observation time, serum-amylase and the tissue content of malondialdehyde, glutathione and histology was studied. Results: Serum amylase in the cerulein group was significantly high(p