간 및 위 , 장관을 침범한 특발성 과호산구 증후군 치험

Marked eosinophilia is found in many kinds of disease state, It usually occur in allergic and parasitic conditions and occ assionally in autoimmune disease, blood dyscrasias, or certain malignancics. Idio- pathic hypereosinophilic syndrome is characterized by markedly elevated peripheral blood eosinophil count without explainable etiology. Eosinophilopoiesis is related with T-lymphocyte activation and cytokine cascade controlling eosinophilic production. It shows tissue infiltration in many organs including endomyocardium, lung, liver, gastrointestinal tract. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 65-year-old woman who had of complained anorexia, weight loss and diarrhea during the past month and half. Persistantly increased eosinophil count was shown in her peripheral blood, the count averaging 3480/mm'(41% in differential count). Abdominal computer tomography disclosed multiple small relatively ill-defined hypoechoic lesions in the liver. Microscopically, the needle biopsy of the liver revealed heavy infiltration by eosinophilis especially in the portal tracts. On reviewing, previously perfomed endoscopic biopsies from the stomach and terminal ileum also had mild to moderate eosinophilic infiltration, respectively. No evidence of parasitic infection was present on the clinical history and laboratory test. Corticosteroid was administered ard brought marked improvement of clinical manifestations including both hematologic and radiologic abnormalities. (Korean J Gastroenterol 1997; 30:397- 403)