급성 B형 간염 환자에서 HBsAg / IgG 면역복합체 측정의 의의

Backgrounds/Aims: HBsAg/IgG immune complexes (ICs) have been found in patients with hepatitis B virus (HBV) infection. To understand the immunologic process in patients with acute viral hepatitis (AVH) B, HRsAg/IgG ICs were quantified. Methods: We serially quantified HBsAg/IgG ICs in patients with A...

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Veröffentlicht in:The Korean journal of gastroenterology 1998-11, Vol.32 (1), p.61
Hauptverfasser: 김홍수, Hong Soo Kim, 이문호, Moon Ho Lee, 김선주, Sun Joo Kim, 황성규, Seong Gyu Hwang, 양동호, Dong Ho Yang, 박필원, Pil Won Park, 박상흠, Sang Heum Park, 정일권, Il Kwun Chung, 홍세용, Sae Yong Hong, 박종면, Jong Myun Park
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Sprache:kor
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Zusammenfassung:Backgrounds/Aims: HBsAg/IgG immune complexes (ICs) have been found in patients with hepatitis B virus (HBV) infection. To understand the immunologic process in patients with acute viral hepatitis (AVH) B, HRsAg/IgG ICs were quantified. Methods: We serially quantified HBsAg/IgG ICs in patients with AVH B by ELISA method (Ag-specific), Results: The ICs were detected in 6 out of 9 cases of AVH B with wide quantitative range from 24 ng/mL to 2,251 ng/mL. In the two cases of high ICs, the ICs were measured as 2,251 ng/mL in the 1st week and 540 ng/mL in the 3rd week. In 4 cases, ICs were detected in relatively low titers from 24 to 186 ng/mL. In all the 6 cases of HBsAg/IgG ICs positive, anti-HBs was all negative, and HBcAb was all positive. In 5 out of the 6 cases, HBsAg was positive. The appearance of ICs was not correlated with the level of serum SGPT or the duration of liver function recovery. Conclusions: HBsAg or anti-HBs were present as HBsAg/ IgG ICs during acute phase of AVH B, in which HBsAg or anti-HBs were not detected by conventional radioimmunoassay (RIA). The HBsAg/IgG ICs could be the viral marker complementing eonventional RIA as qualitative method. The quantitive measurement of HBsAg/IgG ICs might provide better understanding of the immunologic process of AVH B. (Kor J Gastroenterol 1998;32:61 - 68)
ISSN:1598-9992