한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구
Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastri...
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| Veröffentlicht in: | The Korean journal of gastroenterology 1998-01, Vol.31 (2), p.160 |
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| container_title | The Korean journal of gastroenterology |
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| creator | 유재영 Jae Young Yoo 박충기 Choong Kee Park 김학양 Hak Yang Kim 김용범 Yong Bum Kim 주상언 Sang Aun Joo 김우중 Woo Joong Kim 김종혁 Jong Hyeok Kim 남은숙 Eun Sook Nam |
| description | Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p |
| format | Article |
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Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p<0.01). According to Lauren classification of gastric cancer, the number of patients with intestinal type was 13 and diffuse type was 12. Antibodies to CagA were more prevalent in the diffuse type than in the intestinal type (8/12, 67% and 6/13, 46% respectively, p<0.01). Conclusions: Infection with CagA positive H. pylori strain is not associatecl with an increased risk for the development of gastric cancer in Korea. (Korean J Gastroenterol 1998;31:160-166)</description><identifier>ISSN: 1598-9992</identifier><language>kor</language><publisher>대한소화기학회</publisher><subject>CagA ; Chronic gastritis ; Gastric Cancer ; Helicobacter pylori</subject><ispartof>The Korean journal of gastroenterology, 1998-01, Vol.31 (2), p.160</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>유재영</creatorcontrib><creatorcontrib>Jae Young Yoo</creatorcontrib><creatorcontrib>박충기</creatorcontrib><creatorcontrib>Choong Kee Park</creatorcontrib><creatorcontrib>김학양</creatorcontrib><creatorcontrib>Hak Yang Kim</creatorcontrib><creatorcontrib>김용범</creatorcontrib><creatorcontrib>Yong Bum Kim</creatorcontrib><creatorcontrib>주상언</creatorcontrib><creatorcontrib>Sang Aun Joo</creatorcontrib><creatorcontrib>김우중</creatorcontrib><creatorcontrib>Woo Joong Kim</creatorcontrib><creatorcontrib>김종혁</creatorcontrib><creatorcontrib>Jong Hyeok Kim</creatorcontrib><creatorcontrib>남은숙</creatorcontrib><creatorcontrib>Eun Sook Nam</creatorcontrib><title>한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구</title><title>The Korean journal of gastroenterology</title><addtitle>대한소화기학회지</addtitle><description>Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p<0.01). According to Lauren classification of gastric cancer, the number of patients with intestinal type was 13 and diffuse type was 12. Antibodies to CagA were more prevalent in the diffuse type than in the intestinal type (8/12, 67% and 6/13, 46% respectively, p<0.01). Conclusions: Infection with CagA positive H. pylori strain is not associatecl with an increased risk for the development of gastric cancer in Korea. 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Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p<0.01). According to Lauren classification of gastric cancer, the number of patients with intestinal type was 13 and diffuse type was 12. Antibodies to CagA were more prevalent in the diffuse type than in the intestinal type (8/12, 67% and 6/13, 46% respectively, p<0.01). Conclusions: Infection with CagA positive H. pylori strain is not associatecl with an increased risk for the development of gastric cancer in Korea. (Korean J Gastroenterol 1998;31:160-166)</abstract><pub>대한소화기학회</pub><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1598-9992 |
| ispartof | The Korean journal of gastroenterology, 1998-01, Vol.31 (2), p.160 |
| issn | 1598-9992 |
| language | kor |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | CagA Chronic gastritis Gastric Cancer Helicobacter pylori |
| title | 한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구 |
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