한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구

Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p