원발성 위 림프종의 임상연구

Background/Aims: Primary gastric non-Hodgkins lymphoma is rare and represents a minority of 1-7% of all gastric malignancy. Prognosis and early diagnosis remains important. Methods: We analysed clinical and endoscopic findings in 27 patients with primary gastric non-Hodgkins lymphoma between June 1989 and July 1994 at the Asan Medical Center. Results: The prevalence of primary gastric lymphoma occupied 1.2% of all gastric cancers. The most frequent chief complaint was epigastric pain(74%), followed by postprandia] epigastric discomfort (19%), abdominal mass(15%) and gastrointestinal bleeding(11%). Initial endoscopic findings suggested gastric lyrnphoma in 6 cases(22%), advanced gastric cancer in 14 cases(52%) and benign gastric ulcer in 2 cases(7%). The macroscopic type of 15 cases(56%) was ulcerative, while 5(19%) were superficial, 5(19%) giant mucosal fold, and 2(6%) polypoid. Pathologic findings of initial endoscopic biopsy specimens in 18 operated cases were gastric lymphoma in 7 cases, atypical lymphocyte infiltration in 3 cases, adenocarcinoma in 4 cases and ulcer or erosion in 3 cases. Conclusions: A definite diagnosis of primary gastric non-Hodgkins lymphoma was difficu]t to be confirmed by endoscopic examination and biopsy. Recognition of specific endoscopic findings with a high index of suspicions is essential for early diagnosis, and multiple biopsies with/without submucosa are required. (Korean J Gastroenterol 1996;28: 11 - 18)