기타 : 담즙산으로 유도된 백서의 췌장손상에 대한 Prostaglandin E1의 효과

To elucidate the cytoprotective effect of prostaglandin on pancreatic injury, we measured the mortality rate, the degree of pancreatic necrosis, and serum amylase level after prostaglandin E, administration in acute experimental pancreatitis which was induced by the retrograde injection of 5% sodium taurocholate into the biliopancreatic duct of rat. Prostaglandin E, (100 ug/kg Body Weight) were injected subcutaneously after 1 and 6 hour later after taurocholate injection, and normal saline solution (1 ml) to the control group by same method. The obstained results were as follows: 1) The mortality rate upto 72 hour was not different (11%: VS 29 %) in both group, but mortality rate upto 96 hour was significantly reduced in prostaglandin group compared with that of control group (11% vs 58% p