간장및 담도 : 산모와 신생아에서 C형간염바이러스의 수직감염에 관한 연구

In order to confirm the perinatal transmission of hepatitis C virus from pregnant women to newborn infants, anti-HCV was tested in 45 pregnant women and their 46 newborn infants who were negative for HBsAg and IgM anti-HA and who showed elevated ALT in more than 2 follow-up tests. The results were as follows; 1) The mean age of 45 pregnant women was 26.8. There was no significant relationship between epidemiologic factors and elevated ALT in pregnant women. 2) Among 45 HBsAg and IgM anti-HA negative pregnant women, 22 were anti-HBs and anti-HBc positive, 14 were anti-HBc positive only, and 9 were anti-HBs and anti-HBc negative. The degree of abnormal ALT in mothers and infants was unrelated to the hepatitis B viral markers in mothers. There was no significant relationship in the degree of ALT elevation between mothers and infants. 3) Anti-HCV was positive in 7 cases (15.6%) of 45 pregnant women. Anti-HCV was positive in 6 cases (15.2%) of 46 newborn infants. In the 7 anti-HCV positive mothers, anti-HCV was positive for one year or a maximum of four years and ALT was elevated intermittently for more than one year, the same as chronic viral hepatitis. But in the 6 cases of anti-HCV positive infants, anti-HCV disappered within 6 or 12 months in most cases and ALT elevation didnt continue for more than 6 months. 4) Anti-HCV was positive in 4 cases (50%) of 8 newborn infants of anti-HCV positive mothers (p< 0.01). Anti-HCV was positive in 2 (67.7%) of 3 cases whose blood was drawn and stored immediately after birth. The positive rate of anti-HCV was about 15% in 45 pregnant women and their infants who were NANB hepatitis suspects by surrogate tests. Anti-HCV was positive in 50% and ALT was abnormal in all eight infants of chronic HCV carrier mothers. We confirmed the passive transfer of anti-HCV from mother to infant. But we need more evidence to confirm the perinatal transmission of HCV.