간 질환들에 있어서 HBs 항원 및 HBs 항체 공존예에 관한 관찰

A clinica] analysis was made, by enzyme immunoassay, of 64 cases of coexistence of HBs antigen and HBs anti-body in the same serum with the subtype in 12 cases of them being observed. The results were as follows: 1) The overall incidence of coexistence in one period was 1.9% (64/3,395). 2) The highest occurrence rate of coexistence was found in age group of 5th decade: 14 cases (21.9%); in age group of 6th decade: 17 cases (26.6%); and the ratio of male to female was 2.4:l. 3) The diagnostic distributions were 18 cases of liver cirrhosis, 12 cases of hepatoma, 6 cases of chronic active hepatitis, 6 cases of acute viral hepatitis, 7 cases of healthy carrier, and 15 cases were suspected to be chronic hepatitis not confirmed by liver biopsy. 4) In 64 cases of coexistence we studied Hbe antigen and Hbe anti-body in 32 cases. In this study Hbe antigen positive and Hbe antibody negative was found in 18 cases (56.3%); Hbe antigen negative and Hbe antibody positive in 11 cases (34.4%); both Hbe antigen and Hbe antibody vere positive in 1 case (3.1%) and negative in 2 cases (6.2%). 5) The results of subtype were as follows: in 12 cases of HBs antigen positive only, 8 cases were of ay type and the other 4 cases of ay/ad complex type. And in 12 cases of HBs antibody positive onlv, 5 cases v:ere found to be of anti-y type. 5 cases of anti-d type, 1 case of anti-a type and 1 case of anti-y/anti-d complex type. And in 12 cases of HBs antigen and HBs antibody coexistence, ay type antigen were found in 8 cases, and antibody types of these antigen were 8 cases of anti-y type, and 1 case of anti-y/anti-d complex type. In conclusion, although the results of these studies are those of the screening test and have geographic limitation. The coexistance of HBsAg and anti-HBs is considered mostly as a form of seroconversion and rarely as a result of the superinfection with another subtype.