위궤양에 대한 Teprenone ( Selbex ) 의 효과

The balance of mucosal defensive factors and aggressive factors is important for ulcerogenesis. Gastrointestinal mucus is a complex glycoprotein which is secreted from variable types of cells in the gastrointestinal tract. Glycoprotein plays an important role as a mucosal defensive factor.We have treated 30 cases of endoscopically diagnosed gastric ulcers with teprenone (Selbex) for the evaluation of the therapeutic efficacy. Every patient was treated with teprenone 50 mg t.i.d. for 8 weeks and underwent endoscopic, clinical and laboratory assessments before and after 8 weeks of the treatment. Aiajor symptoms of gastric ulcer have been improved in 2 out :30 cases (83.4%) after 8 weeks of the medication with teprenone. While, the improvement of gastric ulcer evaluated by endoscopy was observed in 21 out of 30 cases (70.0%). No significant side effects were observed except a mild elevation of SGOT in one patient.