16 , 16 - Dimethyl prostaglandin E2 및 Urogastrone 투여가 흰쥐 위에 미치는 영향

The effect of 16, 16-dimethyl prostaglandin E, and urogastrone on acute gastric mucosal lesions and DNA contents in the pylorus ligated rats with topical aspirin plus HCl were studied. 16, 16-dimethyl prostaglandin E, and urogastrone significantly reduced the lesion scores in stomach. Also, 16, 16-dimethyl prostaglandin E, and urogastrone significantly increased the DNA contents of oxyntic gland area of stomach, but decreased the DNA contents of antrum of stomach. We concluded that 16, 16-dimethyl prostaglandin E, and urogastrone have the cytoprotective effect on the gastric mucosa injured by topical aspirin plus HCl administration, and this was closely related with increase of DNA contents in stomach.