인슐린비의 존형 당뇨병에서 고해상도 B-Mode 초음파로 측정한 경동맥 내중막두께와 죽상동맥경화증 위험인지들과의 관계

Background: Atherosclerosis is more prevalent in diabetic patients, severe and wide spread than in non-diabetic subjects and clinically evident as macrovascular diseases such as coronary, cerebro- vascular and peripheral arterial diseases which are important causes of frequent morbidity and prematur...

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Veröffentlicht in:Diabetes & metabolism journal 1999-06, Vol.23 (3), p.234
Hauptverfasser: 이현철, Hyun Chul Lee, 남재현, Jae Hyun Nam, 임승길, Seong Kil Lim, 허갑법, Kap Bum Huh, 김경래, Kyeong Rae Kim, 남수연, Soo Yeon Nam, 박석원, Seok Won Park, 안철우, Churl Woo Ahn, 송영득, Young Deuk Song, 김대중, Dae Jung Kim, 고영국, Young Guk Ko
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Zusammenfassung:Background: Atherosclerosis is more prevalent in diabetic patients, severe and wide spread than in non-diabetic subjects and clinically evident as macrovascular diseases such as coronary, cerebro- vascular and peripheral arterial diseases which are important causes of frequent morbidity and premature mortality. But atherosclerotic vascular lesions are not easily detectable, before they advanced and cause symptoms. Measurement of carotid Intima-Media thickness(IMT) by high- resolution B-mode ultrasonography is a useful, non-invasive method to detect early atherosclerotic vascular changes. In this study, we investigated associations of IMT with cardiovascular risk factors. Methods: High-resolution B-mode ultrasono- graphy was performed in 63 non-insulin-dependent diabetic patients in order to determine maximal and mean carotid IMT. Blood pressure, glucose, HbA total cholesterol, HDL cholesterol and triglyceride levels were measured on a regular basis in the last 12 months before the carotid ultrasonography. The mean and last values at the time of the carotid ultrasonography were analyzed in relationship to the IMT.Results: Carotid IMT was increased in NIDDM patients with male sex, smoking habit and hypertension. Systolic blood pressure (r=0.252, p=0.050) and LDL cholesterol levels (r=0.273, p=0.031) at the time of carotid ultrasonography showed a correlation with the IMT. Mean triglyceride (r=0.368, p=0.018) and HbA1c>, levels (r=0.288, p=0.045) of the last 12 months were correlated with the IMT. Conclusion: Increased carotid IMT was associated with male sex, smoking, hypertension, systolic blood pressure, LDL cholesterol, mean HbA, and triglyceride levels.
ISSN:2233-6079