생쥐의 배양 심근세포에 있어서 Bupivacaine 의 독성에 대한 Nerve Growth Factor 의 영향

생쥐의 배양 심근세포에 있어서 Bupivacaine 의 독성에 대한 Nerve Growth Factor 의 영향

Background: We tried to evaluate the cytotoxicity of bupivacaine and the protective effect of nerve growth factor(NGF) on bupivacaine-induced cytotoxicity. Methods: Myocardial ceUs of neonatal mice were cultured for 24 hours in the medium containing bupivacaine only, or for 2 hours with pretreatment...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Daehan oe'sang haghoeji 1999-06, Vol.12 (1), p.73
Hauptverfasser: 조남수, Nam Soo Cho, 조수형, Soo Hyeong Cho, 김용배, Yong Bae Kim, 안태훈, Tae Hun Ahn, 박광철, Kwang Chol Park, 임경준, Kyung Joon Lim, 박승택, Seung Tacck Park, 정연태, Yeun Tai Chung
Format: Artikel
Sprache:kor
Schlagworte:
Bupivacaine
Nerve Growth Factor
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: We tried to evaluate the cytotoxicity of bupivacaine and the protective effect of nerve growth factor(NGF) on bupivacaine-induced cytotoxicity. Methods: Myocardial ceUs of neonatal mice were cultured for 24 hours in the medium containing bupivacaine only, or for 2 hours with pretreatment of NGF following bupivacaine expo- sure. Neutral red(NR) assay, MlT assay, count of beating rate and measurement of lactate dehy- drogenase(LDH) activity were done together with light microscopic observation. Results: l. At NR50 and MTT50 values, concentrations of bupivacaine were 994uM and 980uM, respec- tively. 2. Bupivacaine(100uM
ISSN:1738-8767
2287-1683