Sleep Laboratory Study on Single and Repeated Dose Effects of Paroxetine, Alprazolam and Their Combination in Healthy Young Volunteers

Aims: To evaluate the potential interaction of 20 mg paroxetine and 1 mg alprazolam (early morning once-daily administration) on polysomnographic (PSG) sleep and subjective sleep and awakening quality, both after a single intake and after reaching a steady-state concentration. Methods: Twenty-two (1...

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Veröffentlicht in:Neuropsychobiology 2005-01, Vol.51 (3), p.134-147
Hauptverfasser: Barbanoj, Manuel J., Clos, Susana, Romero, Sergio, Morte, Adelaida, Giménez, Sandra, Lorenzo, José L., Luque, Antonio, Dal-Ré, Rafael
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Sprache:eng
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Zusammenfassung:Aims: To evaluate the potential interaction of 20 mg paroxetine and 1 mg alprazolam (early morning once-daily administration) on polysomnographic (PSG) sleep and subjective sleep and awakening quality, both after a single intake and after reaching a steady-state concentration. Methods: Twenty-two (11 for the PSG) healthy young volunteers of both sexes with no history of sleep disturbances (Pittsburgh Sleep Quality Index
ISSN:0302-282X
1423-0224
DOI:10.1159/000085206