Association of the TNF2 Allele with Eclampsia

The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association be...

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Veröffentlicht in:Gynecologic and obstetric investigation 2004-01, Vol.57 (4), p.204-209
Hauptverfasser: Kaiser, Thomas, Grehan, Madonna, Brennecke, Shaun P., Moses, Eric K.
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Sprache:eng
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Zusammenfassung:The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α –307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α –307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ 2 = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ 2 = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.
ISSN:0378-7346
1423-002X
DOI:10.1159/000076689