The c-src1 gene visualized by in situ hybridization on Xenopus laevis chromosomes

Fluorescent in situ hybridization followed by tyramide signal amplification was used to map the site of the c-src1 gene on Xenopus laevis chromosomes. Positive results were obtained with a cDNA probe of about 1 kb. The c-src1 gene is located in the subcentromeric region in the long arm of one of the acrocentric chromosomes of the G category (classified according to Graf and Kobel, 1991). The c-src1 gene and the Xenopus major histocompatibility complex (MHC) 1b locus, which consists of 20 tandemly arranged gene copies, are situated on different chromosomes of the G category.