Sporadic Metastatic Malignant Peripheral Nerve Sheath Tumour with an NF1 Mutation Responding to Trametinib: A Case Report

Sporadic Metastatic Malignant Peripheral Nerve Sheath Tumour with an NF1 Mutation Responding to Trametinib: A Case Report

Abstract Sporadically occurring malignant peripheral nerve sheath tumours (MPNSTs) can have a variety of genomic alterations including altered NF1, leading to activation of the RAS-RAF-MEK-ERK signalling pathway. Trametinib is an inhibitor of MEK1 and MEK2. Here we present a case of a patient diagno...

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Veröffentlicht in:Case Reports in Oncology 2023-01, Vol.16 (1), p.1-6
Hauptverfasser: Hitchen, Nadia, Cross, Matthew, Laking, George, Connor, Joanna, Korenbaum, Clement
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Asymptomatic
Case Report
Case reports
Chemotherapy
Clinical trials
Conflicts of interest
Cytotoxicity
Diagnosis
Drug therapy
Genetic aspects
Inhibitor drugs
Kinases
malignant peripheral nerve sheath tumour
Metastasis
Mutation
Nervous system tumors
nf1
Patients
Radiation
Sarcoma
Targeted cancer therapy
Tomography
trametinib
Tumors
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Zusammenfassung:Abstract Sporadically occurring malignant peripheral nerve sheath tumours (MPNSTs) can have a variety of genomic alterations including altered NF1, leading to activation of the RAS-RAF-MEK-ERK signalling pathway. Trametinib is an inhibitor of MEK1 and MEK2. Here we present a case of a patient diagnosed with sporadic MPNST with an identified NF1 gene treated successfully with trametinib.
ISSN:1662-6575
1662-6575
DOI:10.1159/000528743