Expression and Prognostic Value of CD44 Standard and Variant v3 and v6 Isoforms in Prostate Cancer

Background: The adhesion molecule CD44 standard (CD44s), and its variant isoforms v3 and v6 are associated with cell–to–cell adhesion. The down–regulation of CD44 standard and its variant isoform CD44v6 is linked with early cancer cell dissemination, but the relationship between CD44v3 and malignant...

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Veröffentlicht in:	European urology 2001-02, Vol.39 (2), p.138-144
Hauptverfasser:	Aaltomaa, S., Lipponen, P., Ala-Opas, M., Kosma, V.-M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Follow-Up Studies Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Hyaluronan Receptors - genetics Male Male genital diseases Medical sciences Middle Aged Prognosis Prostate Cancer Prostatic Neoplasms - genetics Protein Isoforms Tumors
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Zusammenfassung:	Background: The adhesion molecule CD44 standard (CD44s), and its variant isoforms v3 and v6 are associated with cell–to–cell adhesion. The down–regulation of CD44 standard and its variant isoform CD44v6 is linked with early cancer cell dissemination, but the relationship between CD44v3 and malignant features of prostate cancer (PC) has not been established previously. Methods: The expression of CD44s and its CD44v3 and CD44v6 isoforms was analysed by immunohistochemistry in 209 archival PC biopsy specimens to establish their prognostic value. Results: Down–regulation of CD44s and CD44v6 was related to high T classification, metastasis, high Gleason score, DNA aneuploidy, high S–phase fraction, high mitotic index, perineural growth and dense amount of tumour infiltrating lymphocytes (p
ISSN:	0302-2838 1873-7560 1421-993X
DOI:	10.1159/000052428